CryptoPolyTech.com
Crypto, Politics, Tech, Gaming & World News.

Using Nanodiamonds to Stop Melanoma Tumor Metastases | CPT PPP Coverage

 | cutline • press clip • news of the day |

Cryptopolytech (CPT) Public Press Pass (PPP)
News of the Day COVERAGE

200000048 – World Newser
•| #World |•| #Online |•| #Media |•| #Outlet |

View more Headlines & Breaking News here, as covered by cryptopolytech.com


Using Nanodiamonds to Stop Melanoma Tumor Metastases appeared on www.azonano.com by .

In a new study, scientist Rajiv K. Saxena and his team investigated the potential of nanodiamonds in combating tumor metastasis.

Effect of treatment with carbon nanodiamonds on the growth and metastasis of B16F10-Luc2 tumor in mice by bioluminescence imaging. Image Credit: Behera et al

Nanodiamonds, carbon nanoparticles ranging from 2-8 nm in size, are known for their easy functionalization with various groups, including carboxylic groups or drugs. Earlier research has established that actively dividing cells have a higher propensity to absorb nanodiamonds. Notably, epithelial cells treated with carboxylic nanodiamonds exhibited an impaired ability to traverse cell-permeable cellulose membranes.

Focusing on melanoma, a cancer known for its high metastatic potential, the researchers treated B16F10 melanoma cells with carboxylic nanodiamonds in a controlled environment. They then assessed the cells’ migratory and invasive capabilities across polycarbonate membranes featuring 8 µm pores. The findings were revealing: melanoma cells exposed to nanodiamonds were hindered in their ability to migrate, unlike their untreated counterparts, which easily passed through the membrane.

The study extended to in vivo models, where C57Bl/6 mice inoculated with B16F10 melanoma cells were treated with carboxylic nanodiamonds. Remarkably, these mice exhibited minimal or no metastasis, in stark contrast to untreated mice, where tumors not only grew but also spread to new body areas. Furthermore, the survival rate of the nanodiamond-treated, tumor-bearing mice was significantly higher compared to their untreated counterparts.

Gene expression analysis led the authors to theorize that nanodiamonds may block cancer cell detachment from primary tumors and inhibit subsequent metastasis stages, including cell movement and entry into blood vessels. Given these promising results, Saxena and colleagues advocate for further exploration of nanodiamonds as a therapeutic agent in the battle against cancer metastasis.

Journal Reference:

Behera, S. P., et. al. (2023) Carboxyl nanodiamonds inhibit melanoma tumor metastases by blocking cellular motility and invasiveness. PNAS Nexus. doi:10.1093/pnasnexus/pgad359

Source:

FEATURED ‘News of the Day’, as reported by public domain newswires.

Find more, like the above, right here on Cryptopolytech.com by following our extensive quiclick links appearing on images or [NEWSer CHEWSer].
View ALL Headlines & Breaking News here.

Source Information (if available)

This article originally appeared on www.azonano.com by – sharing via newswires in the public domain, repeatedly. News articles have become eerily similar to manufacturer descriptions.

We will happily entertain any content removal requests, simply reach out to us. In the interim, please perform due diligence and place any content you deem “privileged” behind a subscription and/or paywall.

CPT (CryptoPolyTech) PPP (Public Press Pass) Coverage features stories and headlines you may not otherwise see due to the manipulation of mass media.

We compile ‘news of the day’ content in an unbiased manner and contextually classify it to promote the growth of knowledge by sharing it just like Using Nanodiamonds to Stop Melanoma Tumor Metastases

First to share? If share image does not populate, please close the share box & re-open or reload page to load the image, Thanks!

You might also like